Presenters will share findings from a collaborative project between Kent State University and Cleveland Clinic on Level I trauma rooms. The project examines four issues that can compromise efficient and safe care: workflow, interruptions, technology integration and sensory stimuli. Trauma resuscitations consist of procedures that require immediate action for diagnosing & stabilizing injured patients. In a complex environment, maintaining an efficient workflow is challenging. Interruptions can contribute to errors that can cost a patient’s life. Effective technology integration can facilitate task completion. Finally, excessive sensory stimuli, such as noise, can hinder efficient care. Systematic literature reviews, focus groups and multidisciplinary design thinking sessions were utilized as a deep dive to understanding problems in trauma rooms. The next phases of the project included design and development where the research team integrated research into a design studio to develop design variations for the trauma room. To evaluate the design, a full-scale physical mock-up and an augmented reality application were developed and utilized for scenario-based simulations with clinicians. The analysis revealed overlaps among the four categories of issues under study. Findings from this study will inform stakeholders on design strategies that allow for a holistic user-centered design in support of safety and efficiency of care in trauma rooms.